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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMPD1
All Species:
17.88
Human Site:
Y543
Identified Species:
43.7
UniProt:
P17405
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P17405
NP_000534.3
629
69752
Y543
L
Y
R
A
R
E
T
Y
G
L
P
N
T
L
P
Chimpanzee
Pan troglodytes
XP_508253
627
69647
Y541
L
Y
R
A
R
E
T
Y
G
L
P
N
T
L
P
Rhesus Macaque
Macaca mulatta
XP_001110167
629
70027
Y543
L
Y
K
A
R
E
T
Y
G
L
P
N
T
L
P
Dog
Lupus familis
XP_542452
623
69448
Y537
L
Y
R
A
R
E
T
Y
G
L
P
N
A
L
P
Cat
Felis silvestris
Mouse
Mus musculus
Q04519
627
69909
Y541
L
Y
R
A
R
E
T
Y
G
L
P
D
A
M
P
Rat
Rattus norvegicus
Q641Z7
445
49877
K360
N
L
T
E
A
N
L
K
G
E
S
N
W
T
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_683907
591
67552
S504
L
K
P
D
P
R
P
S
W
T
L
L
Y
R
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_611904
735
84165
N618
Y
T
A
R
A
A
Y
N
M
K
A
L
R
P
S
Honey Bee
Apis mellifera
XP_392950
518
60053
L433
N
E
P
S
L
F
D
L
Y
Y
K
H
Y
Y
K
Nematode Worm
Caenorhab. elegans
Q23498
618
71907
V526
A
K
T
Y
F
A
N
V
T
E
A
N
M
K
N
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.7
97.1
84.9
N.A.
82.5
21.6
N.A.
N.A.
N.A.
N.A.
53.4
N.A.
34.2
37.8
35.1
N.A.
Protein Similarity:
100
99
98
89.3
N.A.
88.3
34.5
N.A.
N.A.
N.A.
N.A.
66.6
N.A.
51.4
52.6
52.7
N.A.
P-Site Identity:
100
100
93.3
93.3
N.A.
80
13.3
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
0
0
6.6
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
13.3
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
0
13.3
6.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
10
50
20
20
0
0
0
0
20
0
20
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
10
0
0
10
0
0
0
0
10
0
0
0
% D
% Glu:
0
10
0
10
0
50
0
0
0
20
0
0
0
0
0
% E
% Phe:
0
0
0
0
10
10
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
60
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
20
10
0
0
0
0
10
0
10
10
0
0
10
10
% K
% Leu:
60
10
0
0
10
0
10
10
0
50
10
20
0
40
10
% L
% Met:
0
0
0
0
0
0
0
0
10
0
0
0
10
10
0
% M
% Asn:
20
0
0
0
0
10
10
10
0
0
0
60
0
0
10
% N
% Pro:
0
0
20
0
10
0
10
0
0
0
50
0
0
10
50
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
40
10
50
10
0
0
0
0
0
0
10
10
0
% R
% Ser:
0
0
0
10
0
0
0
10
0
0
10
0
0
0
10
% S
% Thr:
0
10
20
0
0
0
50
0
10
10
0
0
30
10
0
% T
% Val:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
10
0
0
0
10
0
0
% W
% Tyr:
10
50
0
10
0
0
10
50
10
10
0
0
20
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _